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March 18, 2026Biosensors and Bioelectronics0 citationsOpen Access

Smartphone-Assisted Nanosensor for Detecting GHB in Urine

Smartphone-Assisted Lateral Flow Nanosensor for the Selective Detection of GHB in Urine

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Authors

EGEva María Nieto GarridoGHGuillermo Hernández-SigüenzaLMLara Mollà-Guerola

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Overview

Lateral flow nanosensor detects GHB in urine, suggesting a rapid method for on-site forensic analysis.

Key Points

  • To develop a rapid test strip for the selective detection of GHB in urine using mesoporous silica nanoparticles.
  • Utilized mesoporous silica nanoparticles functionalized with a GABA B receptor agonist.
  • Implemented a competitive binding mechanism for GHB detection employing fluorescence readout.
  • Developed a lateral flow assay (LFA) platform integrating the nanosensor for portable usage.
  • Achieved a limit of detection (LOD) of 0.28 μM in diluted urine.
  • Demonstrated high selectivity against common drugs like cocaine and morphine.
  • Rapidly distinguished between physiological and exogenous GHB levels within 1 minute.
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Cite This Study

Garrido et al. (2026) studied this question.

synapsesocial.com/papers/69ba42bc4e9516ffd37a3403https://doi.org/10.1016/j.bios.2026.118628
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