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March 18, 2026Journal of Medicinal ChemistryOpen Access

Brain Permeable SGK1 Inhibitors: A Promising Therapeutic Strategy for Neurodegenerative Diseases

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Authors

EMEnrique López MadrugaAGAlfonso Garcia-RubiaCSCarlos Sanchez-Nuñez

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Overview

Identifies SGK1 inhibitors that penetrate the blood-brain barrier, suggesting new treatments for neurodegenerative diseases.

Key Points

  • The aim is to explore SGK1 as a therapeutic target for neurodegenerative diseases by developing inhibitors that can cross the blood-brain barrier.
  • Mixed ligand- and structure-based virtual screening to identify SGK1 inhibitors.
  • Development and optimization of SGK1 inhibitors for enhanced blood-brain barrier permeability.
  • Medicinal chemistry program generating a new family of SGK1 inhibitors.
  • A new family of SGK1 inhibitors was created that can penetrate the blood-brain barrier.
  • These inhibitors provide tools for investigating SGK1’s role in neurological disorders.
  • SGK1 is highlighted as a potential therapeutic target for conditions like Alzheimer’s disease.

Cite This Study

Madruga et al. (2026) studied this question.

synapsesocial.com/papers/69ba42ee4e9516ffd37a3962https://doi.org/10.1021/acs.jmedchem.5c03050
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