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March 18, 2026PharmataOpen Access

Effects of Borage Oil on Oxidative Damage, Inflammatory Response (IL-6, IL-1β, and TNF- α), and Signaling Pathways (Bax/Bcl-2 and Caspase-3) in Lead Acetate–Induced Nephrotoxicity

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Authors

İBİlyas BozkurtMHMesut Bünyami Halıcı

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Overview

Experimental study shows borage oil reduces oxidative damage in lead-induced kidney injury, suggesting protective potential.

Key Points

  • This research investigates the protective effects of borage oil against lead acetate-induced kidney damage.
  • Evaluated biochemical alterations in rat kidney tissue after exposure to lead acetate.
  • Administered borage oil to different groups of rats for 14 days post lead exposure.
  • Measured malondialdehyde levels and antioxidant enzymes using ELISA and RT-PCR techniques.
  • Analyzed inflammatory markers through Western blot analysis.
  • Lead acetate increased oxidative stress and markers of inflammation in kidney tissue.
  • Borage oil enhanced antioxidant defenses and reduced MDA levels, particularly at 100 mg/kg.
  • Borage oil reduced the expression of pro-inflammatory markers like TNF-α and IL-1β after lead exposure.
  • Borage oil reversed apoptotic changes, increasing Bcl-2 and reducing Bax and caspase-3 levels.

Cite This Study

Bozkurt et al. (2026) studied this question.

synapsesocial.com/papers/69ba431a4e9516ffd37a4034https://doi.org/10.62425/pharmata.1868902
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