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March 18, 2026Cancer Research0 citations

PAK5-Mediated Suppression of β-Hydroxybutyrate Production Promotes Breast Cancer Metastasis and Can Be Overcome with Ketogenic Diet

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YXYao XingYTYongqiang TanBHBei Hu

Key Points

  • To investigate the role of PAK5 in breast cancer metastasis through β-hydroxybutyrate production.
  • Analyzed the phosphorylation effects of PAK5 on HMGCS2.
  • Evaluated breast cancer growth and metastasis in relation to β-hydroxybutyrate levels.
  • Explored the impact of a ketogenic diet on these pathways.
  • PAK5 phosphorylation of HMGCS2 was found to inhibit β-hydroxybutyrate production.
  • Inhibition of β-hydroxybutyrate significantly promoted breast cancer metastasis.
  • A ketogenic diet showed potential to counteract the effects of PAK5 on β-hydroxybutyrate levels.

Abstract

PAK5-mediated phosphorylation of HMGCS2 promotes breast cancer growth and metastasis by inhibiting β-hydroxybutyrate production, revealing the role of PAK5 in ketone metabolism and highlighting a potential therapeutic target for breast cancer metastasis.

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Cite This Study

Xing et al. (2025) studied this question.

synapsesocial.com/papers/69ba434a4e9516ffd37a4535https://doi.org/10.1158/0008-5472.can-25-2174
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