This research evaluates antifungal activity of camphene derivatives in combination with fluconazole against Candida spp., suggesting potential new treatments.
Key Points
The study aims to develop new antifungal agents through the synthesis of camphene derivatives and assess their efficacy against Candida spp.
Synthesize aryl-camphene derivatives using Heck–Matsuda arylation under moderate and aerobic conditions.
Evaluate antifungal activity of synthesized derivatives against Candida spp.
Determine the minimum fungicidal concentration and compare with fluconazole.
Camphene exhibited superior antifungal activity compared to fluconazole against C. albicans.
The combination of camphene and fluconazole significantly reduced the average inhibitory concentration (IC50).
Only the camphene and fluconazole combination demonstrated fungicidal action against C. albicans.
C. tropicalis showed fungicidal activity with both combinations of camphene and fluconazole.