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March 22, 2026Endocrine Metabolic & Immune Disorders - Drug Targets0 citations

Guipi Decoction Reduces Fibrosis And Oxidative Stress In Diabetic Erectile Dysfunction

Guipi Decoction Attenuates Fibrosis and Oxidative Stress to Ameliorate Diabetic Erectile Dysfunction in Rats via the RhoA/ROCK Signaling Pathway

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Authors

SLSun LonghaoShenyang 242 HospitalLJLi JiayunLiaoning University of Traditional Chinese MedicineMYMa YuexinLiaoning University of Traditional Chinese Medicine

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Overview

Demonstrates Guipi Decoction improves erectile function in diabetic rats, suggesting a therapeutic mechanism.

Key Points

  • The research investigates the efficacy of Guipi Decoction in ameliorating Diabetic Erectile Dysfunction (DMED) through the RhoA/ROCK signaling pathway.
  • Used 36 Sprague-Dawley rats, with 6 controls and 30 induced with DMED using STZ.
  • Divided DMED rats into five groups for treatment: Model, Sildenafil, and three Guipi Decoction doses.
  • Treatment lasted 4 weeks with various assessments including blood glucose, erectile function, and oxidative stress markers.
  • DMED model rats had significantly increased blood glucose, triglycerides, and other harmful markers compared to controls (P<0.01).
  • Guipi Decoction improved erectile function and reduced several harmful markers and fibrosis (P<0.01 or P<0.05).
  • Higher doses of Guipi Decoction showed stronger therapeutic benefits.

Cite This Study

Longhao et al. (2026) studied this question.

synapsesocial.com/papers/69bf898bf665edcd009e943ehttps://doi.org/10.2174/0118715303420396251202100011
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