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March 22, 2026Current Aging Science

Ubiquitin-Proteasome System: Key Insights into Neurological Disorder Mechanisms

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Authors

SAShahid AfridiFCFurqan ChoudharyPSPradakshina Sharma

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Overview

Review explores UPS dysfunction in neurodegenerative diseases, suggesting therapeutic approaches to restore protein balance.

Key Points

  • The aim is to explore the role of the ubiquitin-proteasome system in neurological disorders and identify therapeutic strategies.
  • Reviewed literature from diverse databases on UPS and neurological disorders.
  • Examined the role of UPS in maintaining protein homeostasis.
  • Provided insights into UPS-targeted interventions and molecular disruptions.
  • Dysfunction in the UPS leads to neurotoxic protein accumulation.
  • Age-related decline in UPS contributes to neurodegeneration.
  • Targeted degradation of misfolded proteins shows therapeutic potential.

Cite This Study

Afridi et al. (2026) studied this question.

synapsesocial.com/papers/69bf89c1f665edcd009e997fhttps://doi.org/10.2174/0118746098383104251205103934
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