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March 25, 2026Cell MetabolismOpen Access

The many pathways driving liver inflammation in MASH

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Authors

HTHerbert TilgTATimon E. AdolphSRStefano Romeo

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Overview

This review highlights the drivers of liver inflammation in MASH, indicating new therapeutic approaches may improve outcomes.

Key Points

  • The aim is to analyze the complex mechanisms contributing to liver inflammation in MASH and explore potential therapies.
  • Review various mechanisms of liver inflammation in MASH
  • Discuss the role of obesity-related systemic inflammation
  • Examine therapeutic options targeting metabolic and inflammatory pathways
  • Identified multiple pathways leading to inflammation in MASH
  • Highlighted the impact of diet and gut microbiome on liver health
  • Proposed that new therapies could enhance clinical management of liver disease

Cite This Study

Tilg et al. (2026) studied this question.

synapsesocial.com/papers/69c37afeb34aaaeb1a67d01ehttps://doi.org/10.1016/j.cmet.2026.02.018
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