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March 25, 2026Cancer Research

Abstract PR005: Closed-Loop Sonothermogenetic Control of CAR T Cells for Precision Immunotherapy of Brain Tumors

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Authors

CACostas ArvanitisCKChulyong KimAZAli Zamat

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Overview

Demonstrates closed-loop control of CAR T cell activity in brain tumors, suggesting a new approach for effective immunotherapy.

Key Points

  • To develop a remote, noninvasive system for controlling CAR T cell therapy in brain tumors while ensuring safety and efficacy.
  • Engineered CAR T cells with a thermal switch for heat-induced gene expression.
  • Utilized MR-guided focused ultrasound and real-time thermometry for precise temperature control.
  • Employed a closed-loop PID control algorithm to maintain target temperature for CAR T cell activation.
  • Achieved precise temperature control (41.5 ± 0.1 °C) for CAR T cell activation.
  • Induced gene expression returns to baseline within 24 hours but is re-inducible with subsequent heating.
  • Demonstrated significant reduction in tumor-infiltrating MDSCs and improved antitumor responses in murine models.

Cite This Study

Arvanitis et al. (2026) studied this question.

synapsesocial.com/papers/69c37afeb34aaaeb1a67d062https://doi.org/10.1158/1538-7445.brain26-pr005
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Also Consider

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  1. 1Abstract 144: <i>In vivo</i> CAR mRNA engineering of both adaptive and myeloid cells enables potent anti-tumor control of solid cancers.2026 · 1 citations
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  3. 3Abstract A038: Overcoming myeloid-mediated immunosuppression and enhancing blood-brain barrier access to advance B7H3 CAR T cell therapy in high-risk Medulloblastoma2025
  4. 4Smart control of CAR-T cells: emerging strategies for safer and more effective cancer immunotherapy2026 · 3 citations
  5. 5Abstract 3444: Spatial profiling of recurrent glioblastoma in a Phase I clinical trial reveals favorable immune remodeling induced by intracerebroventricular CAR T therapy2026