Continuous-flow synthesis of Pd( ii )-anchored amino-functionalised magnetic silica nanoparticles as a robust recyclable catalyst for aqueous Sonogashira cross-coupling

Key Points

• This research aims to develop a recyclable palladium nanocatalyst for effective Sonogashira cross-coupling in aqueous environments.
• Synthesis of Fe3O4@SiO2-NH2-Pd(II) using continuous-flow coprecipitation/silanisation
• Evaluation of catalytic activity in Sonogashira reactions
• Assessment of magnetic recoverability
• The synthesized catalyst demonstrated high activity in water for Sonogashira cross-coupling
• The palladium nanoparticles remained effective after multiple reaction cycles
• The continuous-flow method provided a scalable approach for catalyst production