Being in the lowest quintile of circadian rest-activity rhythm amplitude was associated with 64% higher odds of cardiovascular disease compared to higher quintiles (OR 1.64; 95% CI 1.11-2.43).
Observational (n=4,893)
Yes
Does disrupted circadian rest-activity rhythm increase the risk of cardiovascular disease and mortality in middle-aged and elderly adults?
Disrupted circadian rest-activity rhythms, particularly low amplitude, are associated with increased odds of cardiovascular disease and mortality, with stronger effects observed in women.
Effect estimate: OR 1.64 (95% CI 1.11-2.43)
Aberrant accelerometry-derived circadian rest-activity rhythm (CRAR) is associated with an increased risk of cardiovascular disease (CVD), yet the potential sex differences in this association among middle-aged and elderly adults remain unclear. This study investigates sex-specific associations between CRAR, CVD, and mortality in a large, diverse U.S. population. We analyzed data from participants aged ≥45 y in the National Health and Nutrition Examination Survey (NHANES) 2011-2014 who completed 7 d wrist actigraphy and had at least four valid 24-h accelerometer recordings. Parametric CRAR measures, including amplitude, mesor, pseudo-F, and acrophase, were derived using an extended cosinor model. Weighted multivariable logistic regression assessed the associations between CRAR measures and the prevalent CVD, while Cox regression models evaluated the associations of CRAR with all-cause and cardiovascular mortality. Among 4893 participants, those in the lowest quintile of CRAR amplitude had 64% higher odds of CVD than those in higher quintiles (95% CI, 1.11-2.43). Low amplitude and mesor were significantly linked to increased risks of all-cause and cardiovascular mortality. Associations between CRAR disruption and outcomes appeared stronger in women, with significant interactions observed for several cardiovascular outcomes. Maintaining a robust circadian rhythm may be important for cardiovascular health and longevity, particularly among women.
Li et al. (2026) conducted an observational in Cardiovascular disease (n=4,893). Lowest quintile of circadian rest-activity rhythm (CRAR) amplitude vs. Higher quintiles of CRAR amplitude was evaluated on Prevalent cardiovascular disease (OR 1.64, 95% CI 1.11-2.43). Being in the lowest quintile of circadian rest-activity rhythm amplitude was associated with 64% higher odds of cardiovascular disease compared to higher quintiles (OR 1.64; 95% CI 1.11-2.43).