Design, green synthesis and biological evaluation of fluorinated N -acyl sulfonamides as novel anti-inflammatory agents: an in vivo and in silico study

Key Points

• The aim is to design and assess the biological efficacy of fluorinated N-acyl sulfonamides as anti-inflammatory agents.
• Developed a green synthesis method for N-acyl sulfonamides.
• Conducted in vivo evaluations of anti-inflammatory activity.
• Performed in silico studies to support biological findings.
• Certain compounds demonstrated superior anti-inflammatory activity compared to diclofenac.
• In silico results corroborated the in vivo findings, indicating strong potential for these novel agents.