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March 25, 2026Organic Letters

Total Syntheses of Roseochelins A and B Using an Oxidative Decarboxylation Strategy

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Authors

MAMikel Jason AllasLBLaura BurchillASAdam W. E. Stewart

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Overview

Concise syntheses of roseochelins A and B demonstrate a new pathway involving oxidative decarboxylation.

Key Points

  • This research aims to achieve the total synthesis of roseochelins A and B through a new oxidative strategy.
  • Conducted total syntheses of roseochelins A and B
  • Utilized biomimetic approaches to mirror proposed biosynthetic pathways
  • Employed metal-catalyzed and photocatalyzed oxidative decarboxylation techniques
  • Successfully synthesized roseochelin A from sinapic acid using metal-catalyzed oxidative decarboxylation
  • Roseochelin B was synthesized through regioselective catechol formation and quinone-mediated thiomethylation
  • Findings revised the understanding of the biosynthetic pathway for roseochelins.

Cite This Study

Allas et al. (2026) studied this question.

synapsesocial.com/papers/69c37bd4b34aaaeb1a67ea79https://doi.org/10.1021/acs.orglett.6c00757
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Also Consider

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