Incidence and Risk Factors of Symptomatic Osteonecrosis in Children With Acute Lymphoblastic Leukemia—A Population‐Based Analysis of the Austrian ALL‐BFM Study Group
Population-based analysis shows age as a key risk factor for osteonecrosis in children with leukemia, indicating the need for monitoring.
Key Points
This analysis aims to determine the incidence and risk factors associated with symptomatic osteonecrosis in children with acute lymphoblastic leukemia.
Nationally representative cohort analysis
Included 1127 pediatric patients with newly diagnosed acute lymphoblastic leukemia
Data collected from AIEOP-BFM-ALL protocols 2000 and 2009
73 patients developed symptomatic osteonecrosis
5-year cumulative incidence was 7% ± 1%
Adolescent patients (10-18 years) had a 22% incidence compared to 2% in younger children.
Age at diagnosis was identified as the only independent predictor for osteonecrosis