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March 26, 2026Atherosclerosis0 citationsOpen Access

Achieving LDL-C <1.0 mmol/L and cardiovascular outcomes in patients with coronary artery disease who received percutaneous coronary intervention

YKYu KataokaSNStephen J. NichollsSKSatoshi Kitahara

Key Points

  • This research aims to evaluate the impact of achieving LDL-C levels below 1.0 mmol/L on cardiovascular outcomes in CAD patients post-PCI.
  • Multi-center observational analysis of 2560 CAD patients receiving PCI from 2017 to 2022.
  • Follow-up for at least three years post-PCI for cardiac events.
  • Comparison of primary and secondary outcomes based on LDL-C levels at two months post-PCI.
  • Only 9.8% of patients achieved LDL-C <1.0 mmol/L post-treatment.
  • Achieving LDL-C <1.0 mmol/L significantly reduced primary outcomes by 77% and secondary outcomes by 69%.
  • Higher rates of intensified lipid-lowering therapies were noted in those who achieved LDL-C <1.0 mmol/L.

Abstract

AbstractBackground and aims The ESC guideline recommends LDL-CMethods The current multi-center observational study analyzed 2560 patients with CAD receiving PCI (2017.1.1-2022.8.31). All of study participants were clinically followed for at least three years after PCI. The primary (cardiac death, non-fatal MI and clinically-driven coronary revascularization at non-culprit segments) and secondary outcomes (cardiac death, non-fatal MI) were compared in those stratified according to on-treatment LDL-C levels at 2 months after PCI (Results On-treatment LDL-CConclusions Achieving LDL-C<1.0 mmol/L mitigated risks of subsequent atherosclerotic cardiovascular events in patients with CAD. More actions are needed to further promote the intensification of lipid-lowering therapies in patients with CAD.

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Cite This Study

Kataoka et al. (2026) studied this question.

synapsesocial.com/papers/69c4cc02fdc3bde448917693https://doi.org/10.1016/j.atherosclerosis.2026.120684
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