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March 28, 2026Kidney International Reports0 citationsOpen Access

Wcn26-8769 Protective Effect of P2y14 Receptor Inhibition in Ischemia-Induced Acute Kidney Injury: Toward the Development of a Novel Therapeutic Strategy

JLJean-Philippe C LavoieCLChristine LégaréSFSonia Francoeur

Key Points

  • The aim is to assess the protective role of P2Y14 receptor inhibition in preventing ischemia-induced acute kidney injury.
  • Analyzed patient health records for acute kidney injury (AKI) diagnosis and recovery rates.
  • Utilized statistical measures for sensitivity and specificity of AKI diagnoses.
  • Categorized AKI severity to assess reporting accuracy.
  • 67% of patients with AKI experienced renal recovery before discharge.
  • Reported sensitivity and specificity of health records for AKI diagnosis were 5.5% and 99.9%, respectively.
  • Sensitivity increased with the severity of AKI (Stage 1: 2%, Stage 2: 4.9%, Stage 3: 20.1%).

Abstract

index AKI (OR 1.82, p <0.003).67% of patients with AKI had renal recovery (SCr <1.5x baseline) prior to hospital discharge.The sensitivity and specificity of health records AKI diagnosis were 5.5% and 99.9%, respectively, with sensitivity increasing based on AKI severity (Stage 1: 2%, Stage 2: 4.9%, Stage 3: 20.1%). Conclusion:AKI is common and clinically significant, yet highly under-reported in hospitalized children.Future research should elucidate reasons for underreporting and evaluate the impact of improving reporting on patient and system outcomes.I have no potential conflict of interest to disclose.I did not use generative AI and AI-assisted technologies in the writing process.

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Cite This Study

Lavoie et al. (2026) studied this question.

synapsesocial.com/papers/69c770418bbfbc51511e080chttps://doi.org/10.1016/j.ekir.2026.104035
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