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April 1, 20260 citationsOpen Access

miR-138-5p Promotes HF in Rats by Reducing Histone Methylation in the Myd88 Promoter Region through Inhibition of EZH2.

YZYang ZhangWLWeihui Lu

Key Points

  • The central aim is to investigate how miR-138-5p influences heart failure by modulating histone methylation in the Myd88 promoter.
  • Experimental design involved in vitro and in vivo rat models.
  • Assessment of EZH2 expression levels and H3K27me3 methylation.
  • Measurement of Myd88 expression and cardiomyocyte apoptosis rates.
  • miR-138-5p expression was found to inhibit EZH2 levels.
  • Reduced H3K27me3 methylation was correlated with increased Myd88 expression.
  • Enhanced Myd88 expression was linked to higher rates of cardiomyocyte apoptosis, suggesting a role in heart failure.

Abstract

miR-138-5p targets and inhibits the expression of the EZH2 gene, reducing H3K27me3 methylation in the Myd88 promoter region, thereby enhancing Myd88 expression, promoting cardiomyocyte apoptosis, and exacerbating HF.

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Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/69ccb59f16edfba7beb8763fhttps://doi.org/10.6515/acs.202603_42(2).20250815a
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