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April 1, 20260 citationsOpen Access

Reconstruction for Rapidly Enlarging Triple-Negative Metaplastic Breast Cancer During...

A case of reconstruction for triple-negative metaplastic breast cancer that enlarged rapidly during neoadjuvant immunochemotherapy

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Authors

KTKazuhiro ToriyamaSYSouji YoshimuraRNRyota Nakamura

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Overview

Case report demonstrates reconstruction success after rapid tumor growth in a female with breast cancer, indicating new surgical approaches may be needed.

Key Points

  • The aim is to describe a surgical approach for a patient experiencing rapid tumor enlargement during immunochemotherapy.
  • Case report on a 47-year-old female with triple-negative metaplastic breast cancer.
  • Received pembrolizumab, paclitaxel, and carboplatin in a neoadjuvant setting.
  • Conducted semi-emergency surgery including right mastectomy and axillary lymph node dissection.
  • Used internal mammary artery perforator flap for reconstruction and skin grafting.
  • Tumor rapidly enlarged necessitating urgent surgical intervention.
  • Patient achieved wound closure after 3 weeks despite partial epidermal necrosis.
  • Chemotherapy resumed 4 weeks post-surgery and radiation therapy started 4.5 months later.
  • Patient remained disease-free 18 months after surgery.
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Cite This Study

Toriyama et al. (2026) studied this question.

synapsesocial.com/papers/69cd7a4e5652765b073a758bhttps://doi.org/10.18999/nagjms.88.1.157
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