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November 24, 2017Hepatology1,542 citations

RNA N6‐methyladenosine methyltransferase‐like 3 promotes liver cancer progression through YTHDF2‐dependent posttranscriptional silencing of SOCS2

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MCMengnuo ChenLWLai WeiCLCheuk‐Ting Law

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Abstract

METTL3 is frequently up-regulated in human HCC and contributes to HCC progression. METTL3 represses SOCS2 expression in HCC through an m6A-YTHDF2-dependent mechanism. Our findings suggest an important mechanism of epigenetic alteration in liver carcinogenesis. (Hepatology 2018;67:2254-2270).

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Chen et al. (2017) studied this question.

synapsesocial.com/papers/69d7e2ebec32c73b01ae32d3https://doi.org/10.1002/hep.29683
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