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April 10, 2026Arquivos de Neuro-Psiquiatria0 citationsOpen Access

The Efficacy of the Naples Prognostic Score in Patients with Carotid Stenosis

DÖDerya ÖzdoğruMEMehmet Necmi EkeİÖİlyas Öztürk

Key Result

A high Naples Prognostic Score was significantly associated with a higher prevalence of severe carotid stenosis compared to a low score (65.3% vs 56.0%, p=0.015).

Key Points

  • This study investigates the relationship between the level of carotid artery stenosis and the Naples Prognostic Score (NPS).
  • Blood samples were taken from patients upon first hospital admission.
  • Patients were classified into low and high Naples groups based on their NPS.
  • Key parameters measured included neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), total cholesterol, and albumin levels.
  • A significant correlation was found between the degree of carotid stenosis and the NPS.
  • NPS was calculated as 0 in 2.6% of patients, 1 in 13.3%, 2 in 32.5%, 3 in 32.8%, and 4 in 18.8%.
  • 40% of patients had a high NLR (> 2.96) while 48.4% had low albumin levels (< 4).

Study Design

Type

Cross-Sectional (n=653)

Multicenter

No

Structured PICO

Does the Naples Prognostic Score correlate with the severity of carotid stenosis?

P
Population
653 patients with carotid stenosis
I
Intervention
High Naples Prognostic Score (NPS 3 and 4)
C
Comparator
Low Naples Prognostic Score (NPS 0, 1, and 2)
O
Outcome
Degree of carotid stenosissurrogate

The Naples Prognostic Score significantly correlates with the degree of carotid stenosis and may serve as a predictive tool for disease severity.

Main Result

Absolute Event Rate: 65.3% vs 56%

p-value: p=0.015

Limitations

  • Retrospective and single-center design
  • Absence of long-term outcomes and follow-up data extending from 6 months to 1 year
  • Morphological characteristics of atherosclerotic plaques and histopathological findings were not systematically evaluated

Abstract

The Naples Prognostic Score (NPS) is widely used, especially in cancer patients. Although it has been emphasized that this scoring system has a strong prognostic power for cardiovascular diseases, studies on cerebrovascular patients are quite limited.To investigate whether there is a relationship between the level of carotid artery stenosis and the NPS.Measurements were taken and recorded using venous blood samples taken from the patients at the time of their first hospital admission. Patients with NPS of 0, 1, and 2 were classified as the low Naples group. Patients with NPS of 3 and 4 were classified as the high Naples group. When analyzing the patients, comparisons were made according to these two separate groups.According to the cut-off values of the neutrophil-to-lymphocyte ratio (NLR; > 2.96), the lymphocyte-to-monocyte ratio (LMR; 2.96), LMR (< 4.44), TG (< 180) and albumin (< 4) cut-off values, and it was 0 in 17 (2.6%) patients, 1 in 87 (13.3%), 2 in 212 (32.5%), 3 in 214 (32.8%), and 4 in 123 (18.8%) subjects.The current study revealed a significant correlation between the degree of carotid stenosis and the NPS, which can be used as a tool to predict the severity of carotid stenosis.

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Cite This Study

Özdoğru et al. (2026) conducted a cross-sectional in Carotid Stenosis (n=653). High Naples Prognostic Score (NPS 3-4) vs. Low Naples Prognostic Score (NPS 0-2) was evaluated on Prevalence of severe (>70%) carotid stenosis (p=0.015). A high Naples Prognostic Score was significantly associated with a higher prevalence of severe carotid stenosis compared to a low score (65.3% vs 56.0%, p=0.015).

synapsesocial.com/papers/69d894326c1944d70ce051d1https://doi.org/10.1055/s-0046-1817033
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