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April 12, 2026Open MedicineOpen Access

Epidemiological trends, antimicrobial resistance, and genetic mutations of Mycoplasma pneumoniae in Wuhan, China: a post-COVID-19 perspective

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Authors

SCShan ChenLLLiang LuoLLLu Liu

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Overview

Investigates antimicrobial resistance and genetic mutations of Mycoplasma pneumoniae infections in Wuhan, indicating urgent surveillance needs.

Key Points

  • The central aim is to investigate the trends in infections and resistance patterns of Mycoplasma pneumoniae in a post-COVID-19 context.
  • Collected 7,234 nasopharyngeal swabs from patients with respiratory symptoms
  • Conducted RT-qPCR to detect Mycoplasma pneumoniae DNA
  • Performed antimicrobial susceptibility testing on cultured isolates
  • Sequenced the 23S rRNA gene to identify mutations related to resistance
  • 19.37% overall positivity rate for Mycoplasma pneumoniae with higher rates in children (32.75%)
  • 20.51% of isolates were susceptible to all tested antibiotics
  • 24.36% exhibited resistance to a single antibiotic class, primarily macrolides (15.38%)
  • 55.13% of isolates showed multidrug resistance mainly driven by macrolide-lincosamide co-resistance
  • 94.87% mutation rate in the 23S rRNA V domain, with A2063G being the most common (65.38%)

Cite This Study

Chen et al. (2026) studied this question.

synapsesocial.com/papers/69db38534fe01fead37c6887https://doi.org/10.1515/med-2026-1400
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