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April 13, 2026Endocrine Related Cancer0 citations

Proteomic Signatures of Adipocyte Recruitment in Breast Cancer

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Authors

DADimitrios G ArgyrisIPIoanna PloumakiTATheodora Argyri

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Overview

Investigates proteomic changes in adipocytes affecting tumor metabolism and angiogenesis in breast cancer, suggesting new therapeutic targets.

Key Points

  • To investigate how breast cancer-associated adipocytes (BrCAAs) are reprogrammed in breast cancer and their role in tumor progression.
  • Established an in vitro BrCAA model using conditioned medium from HCC1143 cells.
  • Conducted mass spectrometry-based proteomics to profile differentially expressed proteins.
  • Performed morphometric analysis in the MMTV-PyMT mouse model to assess adipocyte changes.
  • Identified 256 differentially expressed proteins associated with metabolic shifts in BrCAAs.
  • Observed progressive size reduction and irregularity in adipocytes near tumors, indicating metabolic stress.
  • BrCAAs showed increased endothelial activation and microvessel density, supporting their role in tumor angiogenesis.
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Cite This Study

Argyris et al. (2026) studied this question.

synapsesocial.com/papers/69dc87ea3afacbeac03e9fc6https://doi.org/10.1530/erc-25-0361
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cancer-Associated Adipocytes in Human Breast Cancer: An Observational Histopathological Study of Dedifferentiation and Stromal Transition.2026
  2. 2Cancer-associated adipomes promote invadopodia formation and enhance metastatic potential in triple-negative breast cancer2026 · 2 citations
  3. 3Cancer-associated adipocyte promote progression and immunosuppression in triple-negative breast cancer2026 · 1 citations
  4. 4Cancer-associated adipocytes: metabolic reprogramming, crosstalk and therapeutic implications in tumor progression2026
  5. 5Secreted Factors from Adipose Tissue Reprogram Tumor Lipid Metabolism and Induce Motility by Modulating PPARα/ANGPTL4 and FAK2020 · 37 citations