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April 16, 2026Annals of Hematology0 citationsOpen Access

Donor selection for patients with HLA-homozygous haplotypes in allogeneic hematopoietic stem cell transplantation

NYNoriyoshi YoshinagaMIMakoto IwasakiKKKoji Kato

Key Points

  • To evaluate the impact of donor selection on overall survival in HLA-homozygous transplant recipients.
  • Registry analysis of first allogeneic transplants
  • Comparison of related vs. cord blood donor outcomes
  • Focus on survival rates in different donor scenarios
  • Overall survival rates did not significantly differ between related donor hetero-to-homo and cord blood hetero-to-homo transplantation.
  • Cord blood homo-to-homo transplantation was linked to worse survival outcomes.

Abstract

Registry analysis of first allogeneic transplant in HLA-homozygous recipients.Overall survival did not significantly differ with related donor hetero-to-homo or cord blood hetero-to-homo transplantation.Cord blood homo-to-homo transplantation was associated with inferior survival in the primary analysis.

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Cite This Study

Yoshinaga et al. (2026) studied this question.

synapsesocial.com/papers/69e07cc02f7e8953b7cbde2ehttps://doi.org/10.1007/s00277-026-06994-2
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