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April 16, 2026Chemical Communications0 citationsOpen Access

Copper and manganese diazacalix4arene complexes: structural and cytotoxicity studies and use in ring opening polymerization of ε-caprolactone and δ-valerolactone

ARAzaria C RaziehCRCarl RedshawHSHarry C. Sample

Key Points

  • The study aims to investigate the structural properties and cytotoxic effects of copper and manganese diazacalix[4]arene complexes.
  • Synthesis of metal complexes from M(OAc)2•nH2O (M=Cu, Mn) and p-MeLH4 under aerobic conditions
  • Characterization of complexes through structural analysis
  • Assessment of cytotoxicity in vitro
  • Evaluation of polymerization activity with ε-caprolactone and δ-valerolactone
  • Isolated azacalixarene-metal complexes are thermally stable and non-toxic at low concentrations
  • Successful polymerization of ε-caprolactone and δ-valerolactone observed
  • Complexes demonstrate significant potential for use in materials science applications

Abstract

From reactions of M(OAc)2•nH2O (M = Cu, Mn) or Cu(NO3)2•3H2O with p-methyl-N,N'-dimethyldiazacalix4areneH4 (p-MeLH4) under aerobic conditions, rare examples of azacalixarene-3d-metal complexes were isolated. These, thermally stable non-toxic compounds (≤ µM...

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Cite This Study

Razieh et al. (2026) studied this question.

synapsesocial.com/papers/69e07cc02f7e8953b7cbdf2chttps://doi.org/10.1039/d6cc00888g
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