Demonstrates the antitumor effects of plant-derived particles in non-small cell lung cancer, suggesting therapeutic potential.
Key Points
The study aims to investigate the antitumor effects and mitochondrial mechanisms of Taraxacum mongolicum-derived extracellular vesicle-like particles (TM-EVLPs) on non-small cell lung cancer.
Isolated TM-EVLPs from Taraxacum mongolicum and characterized them through various techniques.
Evaluated cellular uptake and antitumor effects in NSCLC cell lines using multiple assays.
Assessed efficacy and safety in an A549 xenograft mouse model following oral administration of TM-EVLPs.
TM-EVLPs significantly inhibited NSCLC cell viability, migration, and invasion in vitro.
Treatment led to mitochondrial dysfunction evidenced by depolarization of membrane potential and increased oxidative stress markers.
Oral administration in mice resulted in reduced tumor growth and no major organ damage.