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April 21, 2026Microchemical Journal0 citationsOpen Access

Peptide-Based KIM-1 Biosensor Utilizing Computationally Designed CCT3-Derived Peptides

Development of a peptide-based KIM-1 biosensor utilizing computationally designed CCT3-derived peptides

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Authors

MRMuhammad Syafiq Mohd RazibSTShoko TanakaNSNoor Syamila

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Overview

Research demonstrates a peptide-based biosensor effectively detects KIM-1 in urine, indicating potential clinical application.

Key Points

  • This research aims to develop a sensitive peptide-based biosensor for detecting KIM-1, a biomarker for kidney injury.
  • Designed peptides were fused with maltose binding protein for effective expression.
  • Electrochemical methods were used to evaluate the binding affinity and stability of the sensor.
  • Molecular docking and MD simulations assessed peptide interactions with KIM-1.
  • The biosensor exhibited a detection limit of 1.02 ng/mL for KIM-1, within clinically relevant ranges.
  • High specificity and selectivity were demonstrated in both buffer and simulated urine samples.
  • CCT3-BP04 showed better stability and affinity compared to CCT3-BP03 during simulations.
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Cite This Study

Razib et al. (2026) studied this question.

synapsesocial.com/papers/69e7138bcb99343efc98cfc5https://doi.org/10.1016/j.microc.2026.118092
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