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April 21, 2026Current Bioactive Compounds0 citations

Neuroprotective Effects of Tetrahydrocurcumin in Neurodegenerative Diseases

Uncovering the Neuroprotective Effects of Tetrahydrocurcumin in Neurodegenerative Diseases

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Authors

PSPranjal SharmaRVRavinder VermaSBShailendra Bhatt

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Overview

A systematic review explores tetrahydrocurcumin's neuroprotective effects in neurodegenerative diseases, suggesting new therapeutic avenues.

Key Points

  • This research aims to evaluate the neuroprotective properties of tetrahydrocurcumin in various neurodegenerative diseases.
  • Conducted a systematic review using databases like ScienceDirect and PubMed.
  • Analyzed the effects of tetrahydrocurcumin on APP/PS1 mice and BV-2 cytotoxicity.
  • Assessed advancements in nanocarriers for delivering tetrahydrocurcumin.
  • Tetrahydrocurcumin shows significant inhibition of neurodegenerative processes associated with Alzheimer's and Parkinson's diseases.
  • Data indicates that THC can affect Aβ-induced cytotoxicity in microglial cells.
  • Challenges include tetrahydrocurcumin's poor bioavailability and stability issues.
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Sharma et al. (2026) studied this question.

synapsesocial.com/papers/69e71467cb99343efc98dba3https://doi.org/10.2174/0115734072417545251207102148
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