Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
April 25, 2026Journal of Biochemical and Molecular ToxicologyOpen Access

Melatonin and Quercetin Co‐Treatment Attenuates Hepatic Damage in Diabetic Rats by Mitigating Oxidative Stress and Inflammation

View Full Paper
Ask AI
Bookmark
Share

Authors

ÉAÉrique Ricardo AlvesJSJaiurte Gomes Martins da SilvaIMIsmaela Maria Ferreira de Melo

Discussion

Loading...

Member takes

Overview

Randomized trial demonstrates reduced hepatic damage in diabetic rats using melatonin and quercetin, suggesting a potential treatment avenue.

Key Points

  • This research investigates the protective effects of melatonin and quercetin on liver damage caused by diabetes in rats.
  • Diabetic rats were assigned to multiple treatment groups, including controls and those treated with insulin, melatonin, quercetin, or a combination for 30 days.
  • Various parameters including weight, histology, immunohistochemistry, biochemistry, and oxidative stress were evaluated post-treatment.
  • Specific dosages included melatonin (10 mg/kg) and quercetin (40 mg/kg).
  • Blood glucose levels in the melatonin and quercetin groups were similar to non-diabetic controls (89.50 ± 4.92 mg/dL and 90.75 ± 3.88 mg/dL, respectively).
  • Elevated levels of oxidative stress markers were noted in the diabetic control group, with TBARS at 3.10 ± 0.93 nmol/mg and reduced GSH at 12.90 ± 1.03 nmol/mg.
  • Histology indicated significant liver damage in diabetic rats, which was mitigated by the combination treatment of melatonin and quercetin.

Cite This Study

Alves et al. (2026) studied this question.

synapsesocial.com/papers/69ec5b6088ba6daa22daced5https://doi.org/10.1002/jbt.70855
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Quercetin prevents rats from type 1 diabetic liver damage by inhibiting TGF-ꞵ/apelin gene expression2024 · 6 citations
  2. 2Combined use of systemic quercetin, glutamine and alpha-tocopherol attenuates myocardial fibrosis in diabetic rats2022 · 9 citations
  3. 3Determination of insulin resistance, β-cell function and insulin sensitivity using modified homeostatic model assessment in diabetic rats treated with melatonin2025
  4. 4IMPACT OF INSULIN AND MELATONIN ON HEPATIC ANATOMY, CELLULAR BIOCHEMISTRY, AND RECEPTOR EXPRESSION IN DIABETIC HEPATIC DAMAGE2024
  5. 5Thymoquinone attenuates diabetes-induced hepatic damage in rat via regulation of oxidative/nitrosative stress, apoptosis, and inflammatory cascade with molecular docking approach2024 · 17 citations