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April 25, 2026JAMA Network Open1 citationsOpen Access

Early-Onset Metastatic Colorectal Adenocarcinoma Incidence and Survival Among Patients Younger Than 50 Years

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VJValérie JoosteFGFrançois GhiringhelliJNJean-Baptiste Nousbaum

Key Points

  • To assess the incidence and survival rates of early-onset metastatic colorectal adenocarcinoma (EO mADC) in patients younger than 50 years.
  • Cohort study design
  • Analysis of incidence based on metastatic sites, focusing on peritoneal involvement
  • Evaluation of survival improvements over time
  • Incidence of EO mADC increased mainly among patients with multiple metastatic sites and peritoneal involvement.
  • Net survival improved over time, except for those with peritoneal involvement.
  • Intensive treatment is suggested for young adults with EO mADC when peritoneal involvement occurs.

Abstract

In this cohort study, the incidence of EO mADC increased mainly among patients with multiple metastatic sites and those with peritoneum rather than liver or lung involvement. Net survival improved over time except for peritoneal involvement. These results suggest that intensive treatment is needed for young adults with EO mADC when the peritoneum is involved.

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Cite This Study

Jooste et al. (2026) studied this question.

synapsesocial.com/papers/69ec5b8a88ba6daa22dad08ehttps://doi.org/10.1001/jamanetworkopen.2026.8647
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