Canakinumab therapy targeting the IL-1β pathway reduced cardiovascular and all-cause mortality by 31% among patients who achieved the largest reductions in hsCRP.
Does anti-inflammatory therapy targeting the IL-1 pathway reduce atherothrombotic risk in patients with residual inflammatory risk?
Targeting the IL-1β inflammatory pathway provides atheroprotection and reduces cardiovascular mortality in patients with residual inflammatory risk, independent of lipid lowering.
Life-threatening cardiovascular events occur despite control of conventional risk factors. Inflammation, as measured by high-sensitivity C-reactive protein (hsCRP) concentration, is associated with future vascular events in both primary and secondary prevention, independent of usual risk markers. Statins are powerful lipid-lowering agents with clinically relevant anti-inflammatory effects. Recent data support targeting the interleukin (IL)-1-to-IL-6-to-CRP signaling pathway as an adjunctive method for atheroprotection. The CANTOS (Canakinumab Anti-inflammatory Thrombosis Outcomes Study) trial showed that reducing inflammation through IL-1β inhibition significantly reduced vascular risk, beyond that achievable with lipid lowering. CANTOS further demonstrated a 31% reduction in cardiovascular mortality and all-cause mortality among patients treated with canakinumab who achieved the largest reductions in hsCRP, as well as efficacy in high-risk patients with chronic kidney disease and diabetes. This review outlines the clinical implications of CANTOS for patients with "residual inflammatory risk," the potential benefits and risks associated with anti-inflammatory therapy, and the importance of CANTOS for future drug development.
Paul M. Ridker (2018) conducted a review in Atherothrombotic risk. Canakinumab (IL-1β inhibition) was evaluated. Canakinumab therapy targeting the IL-1β pathway reduced cardiovascular and all-cause mortality by 31% among patients who achieved the largest reductions in hsCRP.