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April 28, 2026Journal of the American College of Cardiology175 citations

Postmortem molecular screening in unexplained sudden death

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Key result

Postmortem genetic screening of five candidate genes in 12 adults with unexplained sudden cardiac death identified a HERG mutation in 2 patients (16.7%).

Authors

SCSumeet S. ChughOSOlga SenashovaAWAllison W. Watts

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Overview

Low-yield candidate-gene testing in unexplained SCD; leaves open the clinical utility of broader postmortem genetic screening pending larger studies.

Study Design

Type

Observational (n=12)

PICO

P
Population
Unexplained sudden cardiac death (n=12)
I
Intervention / Comparator
Postmortem genetic analysis of candidate genes
O
Primary Outcome
Prevalence of defects in arrhythmia-related candidate genes
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Cite This Study

Chugh et al. (2004) conducted an observational in Unexplained sudden cardiac death (n=12). Postmortem genetic analysis of candidate genes was evaluated on Prevalence of defects in arrhythmia-related candidate genes. Postmortem genetic screening of five candidate genes in 12 adults with unexplained sudden cardiac death identified a HERG mutation in 2 patients (16.7%).

synapsesocial.com/papers/69f0cfdeb606b7e8fdeb2f27https://doi.org/10.1016/j.jacc.2003.11.052
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