Chamber‐Specific Decellularized Extracellular Matrices Differentially Modulate Cardiomyocyte Subtypes to Drive Engineered Heart Tissue Development and Function
Randomized trial investigates how chamber-specific ECMs influence cardiomyocyte maturation, indicating new strategies for engineered heart tissues.
Key Points
This research aims to explore the unique roles of chamber-specific extracellular matrices in cardiac tissue engineering and cardiomyocyte maturation.
Investigated the effects of ventricular and atrial decellularized extracellular matrices on induced pluripotent stem cell-derived cardiomyocyte subtypes.
Conducted proteomic analysis to determine compositional differences between ventricular and atrial matrices.
Analyzed structural maturation and calcium handling in cardiomyocytes based on encapsulation timing.
Ventricular cardiomyocytes (CMs) showed enhanced maturation and function in ventricular decellularized extracellular matrix (vtdECM).