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May 8, 2026Journal of Integrative Plant Biology

Arabidopsis inositol polyphosphate kinase activities regulate COP9 deneddylation functions in phosphate homeostasis

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Authors

YWYashika WaliaMNMedha NoopurIBIshana Bhattacharya

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Overview

Randomized trial demonstrates that inositol polyphosphate kinases modulate phosphate starvation responses in plants, indicating their role in nutrient sensing.

Key Points

  • This research aims to understand the role of inositol polyphosphate kinases in regulating COP9 signalosome activity and its implications for phosphate homeostasis in plants.
  • Investigated interactions between Arabidopsis thaliana InsP-kinases (IPK1 and ITPK1) and the COP9 signalosome (CSN) holo-complex.
  • Analyzed the effects of ITPK1 deficiency on neddylation rates and CRL dynamics.
  • Applied pharmacological approaches to observe effects on SPX4 stability in wild-type and mutant plants.
  • ITPK1 deficiency leads to reduced Nedd8 processing rates, increasing neddylated cullins and disturbing CSN dynamics.
  • Pharmacological inhibition of cullin neddylation stabilizes SPX4, impairing the phosphate starvation response (PSR).
  • Inhibiting CSN5 deneddylase activity induces PSR phenotypes in wild-type plants similar to those seen in InsP-kinase mutants.

Cite This Study

Walia et al. (2026) studied this question.

synapsesocial.com/papers/69fd7eb0bfa21ec5bbf06f62https://doi.org/10.1111/jipb.70268
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