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May 8, 2026Neurology India0 citationsOpen Access

Intracranial Artery Calcification Subtypes Linked to Ischemic Stroke Severity

Subtypes of Intracranial Artery Calcification and Ischemic Stroke Severity

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Authors

DBDren BoshnjakuIPIgor PetrovPWPer Wester

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Overview

Prospective observational study reveals significant correlation between calcification subtypes and disability in ischemic stroke patients.

Key Points

  • This study investigates how different subtypes of intracranial artery calcification relate to neurological disability in ischemic stroke patients.
  • Included 135 patients with a mean age of 67.5 years in a prospective observational study.
  • Categorized patients based on non-contrast computed tomography scans into three groups: without calcification, mainly intimal, and predominant medial calcification.
  • Assessed neurological evaluation using the NIHSS and modified Rankin Scale upon admission and discharge.
  • Patients with predominant medial calcification were older than those with intimal or no calcification (73.5 ± 9.7 vs. 64.1 ± 11.7 vs. 59 ± 12.6 years, P < 0.001).
  • Intimal calcification linked to higher NIHSS scores at discharge (7.8 ± 4.6) compared to medial (5.6 ± 3.8) or no calcification (6.4 ± 4.4), P = 0.03.
  • Linear regression showed intimal calcification had a significantly higher NIHSS score at discharge (β = 4.8, 95% CI: 1.70-7.95, P = 0.003).
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Boshnjaku et al. (2026) studied this question.

synapsesocial.com/papers/69fd7f25bfa21ec5bbf0791ehttps://doi.org/10.4103/neurol-india.neurol-india-d-25-00728
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