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May 8, 2026European Stroke JournalOpen Access

Abstract Number: Esoc2026ys212 Acute Hypertensive Hemorrhagic Stroke Has a Unique Expression Profile of Long Non-Coding Rna in Plasma Exosomes

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Authors

JLJiangmin Li

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Overview

Randomized trial identifies novel plasma biomarkers in acute hypertensive hemorrhagic stroke, suggesting potential for improved diagnosis and prognosis.

Key Points

  • The aim is to discover non-invasive biomarkers for acute hypertensive hemorrhagic stroke through the analysis of lncRNA expression in plasma exosomes.
  • Identified 352 differentially expressed lncRNAs with bioinformatics analysis.
  • Performed qRT-PCR validation on selected lncRNAs such as NONHSAG111409.
  • Analyzed enrichment of target genes in various signaling pathways.
  • 76 lncRNAs were upregulated and 276 downregulated in HICH patients.
  • Bioinformatics revealed enrichment in pathways like IL-17 signaling and glycolipid biosynthesis.
  • Identification of a specific lncRNA expression profile offers potential for novel biomarkers related to disease diagnosis.

Cite This Study

Jiangmin Li (2026) studied this question.

synapsesocial.com/papers/69fd7f4fbfa21ec5bbf07d50https://doi.org/10.1093/esj/aakag023.1247
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