Patients with metabolic syndrome demonstrated early diastolic dysfunction, mitochondrial impairment, and microvascular disturbances contributing to fibrotic changes in the myocardium.
Observational
Patients with metabolic syndrome exhibit early structural and functional myocardial changes, including diastolic dysfunction and fibrosis, highlighting the need for early intervention to prevent heart failure.
This study aimed to evaluate early structural and functional myocardial changes in patients with metabolic syndrome. A clinico-morphological approach was applied, including anthropometric, biochemical, and echocardiographic assessments1,2,3. Insulin resistance was evaluated using the HOMA-IR index. The results demonstrated early diastolic dysfunction, mitochondrial impairment, and microvascular disturbances, contributing to fibrotic changes in the myocardium. These findings highlight the importance of early diagnosis and pathogenetic treatment to prevent progression to heart failure.
Nigoraxon Ravshanbek kizi Madraximova (2026) conducted an observational in Metabolic syndrome. Patients with metabolic syndrome demonstrated early diastolic dysfunction, mitochondrial impairment, and microvascular disturbances contributing to fibrotic changes in the myocardium.