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May 16, 2026European Respiratory Journal

Nasal nitric oxide combined with clinical features for preliminary screening of primary ciliary dyskinesia in bronchiectasis

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Authors

SHShunlian HuXSXiyue ShenYWYì Wáng

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Overview

Randomized trial identifies primary ciliary dyskinesia in bronchiectasis, suggesting effective screening methods.

Key Points

  • The aim is to identify primary ciliary dyskinesia among patients with bronchiectasis using nasal nitric oxide and clinical features.
  • Cross-sectional study of bronchiectasis patients from the BE-China registry
  • Patients underwent structured diagnostic work-up including transmission electron microscopy and whole exome sequencing
  • Diagnoses followed the 2025 ERS/ATS PCD guidelines.
  • 27 out of 373 patients (7.4%) were diagnosed with PCD, comprising 14 confirmed cases and 13 highly likely cases
  • nNO exhibited high screening accuracy with sensitivity 84.8% and specificity 97.1%
  • Strong associations were found between PCD and lower BMI (RC −1.5), FEV1% predicted (RC −18.4), FVC% predicted (RC −11.3), and rhinosinusitis (OR 25.3).

Cite This Study

Hu et al. (2026) studied this question.

synapsesocial.com/papers/6a080af2a487c87a6a40cf71https://doi.org/10.1183/13993003.02796-2025
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Value of Nasal Nitric Oxide Measurement in the Diagnosis of Primary Ciliary Dyskinesia2026
  2. 2Case Report: Primary ciliary dyskinesia due to CCNO mutations: a Chinese pediatric case series and literature review2024 · 4 citations
  3. 3The utility of nasal nitric oxide in the diagnostic evaluation of primary ciliary dyskinesia2024 · 2 citations
  4. 4An international collaborative initiative to screen primary ciliary dyskinesia with high-speed video microscopy and nasal nitric oxide at a tertiary referral centre in South India2026 · 2 citations
  5. 5D91-07 Excessive Immune and Inflammatory Activation in Primary Ciliary Dyskinesia: Association With Bronchiectasis in Children2026