Why the study?
To investigate the association between in-hospital dynamic elevation of hs-cTnT and both early neurological deterioration and 3-month functional outcomes in patients with acute ischemic stroke.
Does dynamic elevation of hs-cTnT predict early neurological deterioration and poorer 3-month functional outcomes in patients with acute ischemic stroke?
Population
1049 acute ischemic stroke patients with two in-hospital hs-cTnT measurements
Comparison
In-hospital hs-cTnT dynamic elevation (>20% increase from baseline) vs non-elevation
Design
Retrospective database analysis
Follow-up
3 months
Key result
Dynamic elevation of high-sensitivity cardiac troponin T in patients with acute ischemic stroke was independently associated with a reduced likelihood of 3-month functional independence (OR 0.67).
Authors
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May inform prognosis in acute ischemic stroke; leaves open whether targeting dynamic hs-cTnT elevation improves outcomes.
Cohort (n=1,049)
Yes
Does dynamic elevation of hs-cTnT predict early neurological deterioration and poorer 3-month functional outcomes in patients with acute ischemic stroke?
Effect estimate: OR 0.67 (95% CI 0.47-0.97)
Absolute Event Rate: 36.71% vs 48.71%
p-value: p=0.036
In patients with acute ischemic stroke, in-hospital dynamic elevation of hs-cTnT is an independent predictor of early neurological deterioration and worse 3-month functional outcomes.
XI et al. (2026) conducted a cohort in Acute ischemic stroke (n=1,049). Dynamic elevation of high-sensitivity cardiac troponin T (hs-cTnT) vs. Non-dynamic elevation of hs-cTnT was evaluated on 3-month functional independence (mRS score 0-2) (OR 0.67, 95% CI 0.47-0.97, p=0.036). Dynamic elevation of high-sensitivity cardiac troponin T in patients with acute ischemic stroke was independently associated with a reduced likelihood of 3-month functional independence (OR 0.67).