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May 20, 2026Actas Dermo-Sifiliográficas0 citationsOpen Access

Androgenetic Alopecia: Narrative Review of Current Therapies and Proposal of a Practical Algorithm for Pharmacological Treatment

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AZA. Gómez ZubiaurSVS. Vañó-GalvánGGG. Garnacho-Saucedo

Key Points

  • This review summarizes current therapeutic options for androgenetic alopecia and proposes a management algorithm.
  • Narrative review of existing therapies for androgenetic alopecia.
  • Evaluation of efficacy and safety of approved treatments.
  • Proposal of a practical algorithm for personalized therapy selection.
  • 80% of White men and 40% of women show signs of androgenetic alopecia by age 70.
  • Currently approved therapies demonstrate safety and clinical efficacy.
  • Additional therapies are effective but lack randomized clinical trial validation.

Abstract

Androgenetic alopecia (AGA) is characterized by a progressive reduction in hair density, typically following a defined pattern. By the age of 70 years or older, 80% of White men and up to 40% of women show signs of AGA, with a substantial impact on mental health and quality of life, particularly among women. Currently, treatments approved by American and European regulatory agencies have demonstrated safety and efficacy in the management of this condition. However, several additional therapies have also shown effectiveness, although the absence of randomized clinical trials has limited their inclusion in the Summary of Product Characteristics (SmPC). Therefore, this review aims to summarize currently available treatments and propose a practical management algorithm to help clinicians select the most appropriate therapy for each patient according to clinical experience and disease severity.

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Cite This Study

Zubiaur et al. (2026) studied this question.

synapsesocial.com/papers/6a0d4e9df03e14405aa99ca5https://doi.org/10.1016/j.ad.2026.104687
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