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May 20, 2026American Journal of Respiratory and Critical Care Medicine0 citations

Ocrelizumab and Organizing Pneumonia: A Diagnostic Challenge

C42-36 Ocrelizumab and the Hidden Pattern of Organizing Pneumonia

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Authors

IVI V VargasEAE Albert-StoneSAS Amin

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Overview

Case presentation reveals organizing pneumonia in a multiple sclerosis patient treated with ocrelizumab, suggesting the need for awareness of this rare complication.

Key Points

  • This case aims to highlight the diagnostic challenges of organizing pneumonia associated with ocrelizumab therapy in multiple sclerosis patients.
  • Case presentation of a 39-year-old man with relapsing remitting multiple sclerosis on ocrelizumab, showing persistent pneumonia-like symptoms.
  • Initial imaging revealed ground glass opacities, followed by bronchoscopy and bronchoalveolar lavage that indicated lymphocyte predominance.
  • A surgical lung biopsy was performed, confirming acute lung injury consistent with organizing pneumonia.
  • The patient experienced rapid improvement with corticosteroid treatment after diagnosis was suspected and before confirmation through biopsy.
  • Follow-up imaging two months later showed marked improvement but revealed residual left upper lobe fibrosis and volume loss.
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Cite This Study

Vargas et al. (2026) studied this question.

synapsesocial.com/papers/6a0d4fa9f03e14405aa9affehttps://doi.org/10.1093/ajrccm/aamag162.3008
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