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September 10, 2025Journal of Ovarian ResearchOpen Access

STAT1β modulates the tumor immune microenvironment to improve prognosis in ovarian cancer: a comprehensive study of transcriptional and protein expression differences

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Authors

NLNing LanXLXintong LiYQYushan Qiao

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Overview

Integrated analysis reveals STAT1β as a protective prognostic factor in ovarian cancer, suggesting it modulates CD8 T-cell activity and M2-TAMs.

Key Points

  • Higher levels of STAT1β enhance CD8 T-cell infiltration while suppressing M2 tumor-associated macrophages.
  • Multivariate Cox regression indicates STAT1β significantly improves prognosis in ovarian cancer with HR = 0.74.
  • Functional enrichment analyses demonstrate that STAT1 expression can modify T-cell dysfunction and regulate immune responses.
  • The findings highlight the role of STAT1 isoforms in tumor immunology and their therapeutic implications in ovarian cancer.

Cite This Study

Lan et al. (2025) studied this question.

synapsesocial.com/papers/68c1d03554b1d3bfb60f6c43https://doi.org/10.1186/s13048-025-01780-6
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