Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 18, 2025Journal of the American Society of Nephrology

High Phosphate and Low Protein Mediate Arterial and Cutaneous Vascular Calcification in CKD Mice

View Full Paper
Ask AI
Bookmark
Share

Authors

YJYing JinFCFei CaoYXYangzhouyun Xie

Discussion

Loading...

Member takes

Overview

Novel diet strategy promotes vascular calcification in CKD mice, highlighting roles of phosphate and p38 MAPK signaling.

Key Points

  • The high phosphate and low protein diet significantly induced vascular calcification in CKD mice, impairing kidney function.
  • Calcification was assessed using micro-CT scans and biochemical staining, revealing extensive arterial and cutaneous changes.
  • Assessment included evaluation of kidney fibrosis with RNA sequencing to identify pivotal molecular pathways in the disease.
  • Inhibition of p38 MAPK signaling effectively reduced vascular calcification and kidney fibrosis, indicating a potential therapeutic target.

Cite This Study

Jin et al. (2025) studied this question.

synapsesocial.com/papers/68d461c231b076d99fa60e8fhttps://doi.org/10.1681/asn.0000000875
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Associations of urinary fetuin-A with histopathology and kidney events in biopsy-proven kidney disease2024 · 11 citations
  2. 2Adenine-induced animal model of chronic kidney disease: current applications and future perspectives2024 · 78 citations
  3. 3Carbonylation of Runx2 at K176 by 4-Hydroxynonenal Accelerates Vascular Calcification2024 · 40 citations
  4. 4Phosphate intake, hyperphosphatemia, and kidney function2022 · 62 citations
  5. 5p38 MAPK activity is associated with the histological degree of interstitial fibrosis in IgA nephropathy patients2019 · 34 citations