A new formula predicting creatinine clearance from serum creatinine in adult males shows a correlation coefficient of 0.83 with measured Ccr values.
Does a new formula incorporating serum creatinine, age, and body weight accurately predict creatinine clearance in adult patients?
A newly developed formula incorporating serum creatinine, age, and body weight provides a reasonable prediction of creatinine clearance in adults.
A formula has been developed to predict creatinine clearance (Ccr) from serum creatinine (Scr) in adult males: (see article)(15% less in females). Derivation included the relationship found between age and 24-hour creatinine excretion/kg in 249 patients aged 18-92. Values for Ccr were predicted by this formula and four other methods and the results compared with the means of two 24-hour Ccr's measured in 236 patients. The above formula gave a correlation coefficient between predicted and mean measured Ccr's of 0.83; on average, the difference predicted and mean measured values was no greater than that between paired clearances. Factors for age and body weight must be included for reasonable prediction.
Cockcroft et al. (1976) studied this question. A new formula predicting creatinine clearance from serum creatinine in adult males shows a correlation coefficient of 0.83 with measured Ccr values.