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August 28, 2011New England Journal of Medicine8,993 citationsOpen Access

Apixaban versus Warfarin in Patients with Atrial Fibrillation

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CGChristopher B. GrangerJAJohn H. AlexanderJMJohn J.V. McMurray

Key Result

Apixaban was superior to warfarin in preventing stroke or systemic embolism and caused less bleeding and lower mortality in patients with atrial fibrillation.

Key Points

  • This research evaluates the effectiveness of apixaban compared to warfarin in preventing strokes in atrial fibrillation patients.
  • Randomized trial design with patients diagnosed with atrial fibrillation
  • Participants received either apixaban or warfarin
  • Followed patients for outcomes related to stroke, bleeding, and mortality.
  • Apixaban significantly reduced stroke or systemic embolism compared to warfarin (exact rates not provided).
  • Bleeding episodes were less frequent with apixaban, enhancing safety.
  • Mortality rates were lower in the apixaban group, indicating potential long-term benefits.

Structured PICO

Does apixaban prevent stroke or systemic embolism in patients with atrial fibrillation?

P
Population
Patients with atrial fibrillation
I
Intervention
apixaban
C
Comparator
warfarin
O
Outcome
stroke or systemic embolismcomposite

In patients with atrial fibrillation, apixaban is superior to warfarin for preventing stroke or systemic embolism, with the added benefits of less bleeding and lower mortality.

Abstract

In patients with atrial fibrillation, apixaban was superior to warfarin in preventing stroke or systemic embolism, caused less bleeding, and resulted in lower mortality. (Funded by Bristol-Myers Squibb and Pfizer; ARISTOTLE ClinicalTrials.gov number, NCT00412984.).

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Cite This Study

Granger et al. (2011) studied this question. Apixaban was superior to warfarin in preventing stroke or systemic embolism and caused less bleeding and lower mortality in patients with atrial fibrillation.

synapsesocial.com/papers/69813150ce4d1f8e18d4e85fhttps://doi.org/10.1056/nejmoa1107039
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Apixaban in Patients with Atrial Fibrillation2011 · 2,433 citations
  2. 2Apixaban for Stroke Prevention in Atrial Fibrillation: A Review of the Clinical Trial Evidence2011 · 3 citations
  3. 3Apixaban in Comparison With Warfarin in Patients With Atrial Fibrillation and Valvular Heart Disease2015 · 245 citations
  4. 4More light at the end of the tunnel – apixaban in atrial fibrillation2012 · 1 citations
  5. 5Efficacy and Safety of Apixaban Compared With Warfarin in Patients With Atrial Fibrillation and Peripheral Artery Disease: Insights From the ARISTOTLE Trial2017 · 42 citations