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March 5, 2026Breast Cancer Research0 citationsOpen Access

Distinct Venule Populations and Tumor Endothelial Cell Markers in Breast Cancer

Transcriptomic profiles from normal and tumor tissue samples reveal distinct venule populations and novel tumor endothelial cell markers in breast cancer

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Authors

KPKathryn N. PhoenixVSVijender SinghPMPatrick J. Murphy

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Overview

Transcriptomic analysis reveals tumor endothelial cell differences, indicating potential therapeutic targets in breast cancer.

Key Points

  • This research aims to identify and characterize different populations of endothelial cells in breast tumors compared to normal tissue.
  • Utilized public single-cell RNA sequencing datasets.
  • Integrated gene expression data from normal and tumor breast samples.
  • Clustered endothelial cells and assessed differential gene expression.
  • Summarized correlations between endothelial markers and patient survival outcomes.
  • Identified distinct venule populations in breast tumor endothelial cells compared to normal cells.
  • Novel markers like CLEC14a, EMCN, and ADM5 were found highly specific to tumor endothelial cells.
  • ADM5 linked to poorer survival in specific breast cancer subtypes and across multiple cancer types.

Cite This Study

Phoenix et al. (2026) studied this question.

synapsesocial.com/papers/69a91d7cd6127c7a504c059ehttps://doi.org/10.1186/s13058-026-02249-0
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