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March 8, 2026Open Access

Antibiotic Prescribing for Group B Streptococcus Coverage in Preterm Prelabour Rupture of Membranes: A Retrospective Cohort Study

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Authors

EAElaf AbuelgasimMMMark McIntyreNTNajla Tabbara

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Overview

Retrospective cohort study identifies variations in GBS antibiotic prescribing in preterm PPROM, suggesting a need for consensus.

Key Points

  • The study aims to evaluate the variability in prescribing GBS-covering antibiotics to pregnant women with PPROM and explore maternal factors influencing such prescribing.
  • Retrospective cohort design involving pregnant women with PPROM in 2024.
  • Included patients were prescribed azithromycin and were not in active labour.
  • Compared maternal characteristics based on GBS status.
  • Used odds ratios to assess associations between prescribing and maternal factors.
  • 146 patients were included from 181 admissions assessed for eligibility.
  • GBS status: 13% negative, 5% positive, and 82% unknown at diagnosis.
  • 63% of patients with positive GBS and 21% of negative patients received GBS-covering antibiotics.
  • 93% of prescribed regimens were aminopenicillin-based or penicillin.
  • Only GBS status was associated with antibiotic prescribing; other maternal characteristics showed no significant association.

Cite This Study

Abuelgasim et al. (2026) studied this question.

synapsesocial.com/papers/69ada8c2bc08abd80d5bc15ahttps://doi.org/10.3390/pharma5010008
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Is expectant management of late preterm prelabor rupture of membranes an option in patients with Group B streptococcus colonization?2025
  2. 2Comparative Effectiveness of Alternate Antibiotic Therapies for Intrapartum Group B Streptococcus Colonization2024 · 1 citations
  3. 3Group B Streptococcus colonization status and antibiotic use during labour – a single-centre observational study2024 · 2 citations
  4. 4Comment on “Ampicillin and Gentamicin Prophylaxis Is Superior to Ampicillin Alone in Patients With Prelabor Rupture of Membranes at Term: The Results of a Randomized Clinical Trial”2026
  5. 5Abstract 14: Group B Streptococcal Colonization - A Silent Threat to Feto-maternal Wellbeing2026