Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
March 25, 2026Cancer Research

Abstract IA005: Shaping tumor cell plasticity and therapy resistance in glioblastoma

View Full Paper
Ask AI
Bookmark
Share

Authors

AIAntonio Iavarone

Discussion

Loading...

Member takes

Overview

Finds tumor cell plasticity and clonal evolution influence therapy resistance in glioblastoma, suggesting new treatment strategies.

Key Points

  • The research aims to investigate how tumor cell plasticity and genetic diversification contribute to therapy resistance in glioblastoma.
  • Utilized spatial and genetic platforms for single cell resolution analysis.
  • Investigated whole glioblastoma sections to establish clustered cell identity.
  • Employed single cell DNA sequencing combined with transcriptome analysis on patient-matched glioblastoma pairs.
  • Conducted experiments with preclinical tumor models to trace lineages of persister subclones.
  • Identified a bottleneck model as the predominant pattern of glioblastoma evolution.
  • Discovered a rare persister subclonal state linked to tumor recurrence and phenotypic changes.
  • Persister cells lacked spatial segregation and served as predictors for timing of recurrence in glioblastoma patients.

Cite This Study

Antonio Iavarone (2026) studied this question.

synapsesocial.com/papers/69c37b62b34aaaeb1a67dc1ehttps://doi.org/10.1158/1538-7445.brain26-ia005
View Full Paper
Ask AI
Bookmark
Share