10万人のヒトがんゲノム解析により腫瘍変異負荷の全体像を明らかにする

Chalmersら（木曜日）がこの問題を研究しました。

www.synapsesocial.com/papers/69d7cddd05ee2ba81dbee181 — DOI: https://doi.org/10.1186/s13073-017-0424-2

Also consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1. Highly penetrant hereditary cancer syndromes· 2004 · 373 citations
2. Lynch syndrome: genetics, natural history, genetic counseling, and prevention.· 2000 · 98 citations
3. First-line chemoimmunotherapy in metastatic breast carcinoma: combination of paclitaxel and IMP321 (LAG-3Ig) enhances immune responses and antitumor activity· 2010 · 254 citations
4. An integrative approach to predicting the functional effects of non-coding and coding sequence variation· 2015 · 740 citations
5. Fast and accurate short read alignment with Burrows–Wheeler transform· 2009 · 62,309 citations