Mitoxantrone was identified as a translation inhibitor targeting the bacterial ribosome with an IC50 of 14.10 mM, demonstrating a bacteriostatic effect comparable to Clindamycin.
in vitro model targeting the bacterial ribosome peptidyl transferase center (PTC) of E. coli
Mitoxantrone, Plerixafor, Olcegepant, and Ziritaxestat
Inhibition of E. coli protein synthesis
A computational pipeline and in vitro validation successfully identified several small molecules, including Mitoxantrone, as inhibitors of bacterial protein synthesis.
A hierarchical VS pipeline to target the bacterial ribosome PTC and in vitro translation assays identified Mitoxantrone as a potent inhibitor of E. coli protein synthesis, and Plerixafor, Olcegepant, and Ziritaxestat as lead compounds.
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Merve Yuce
Ezgi Koman
Fethiye Aylin Sungur
RSC Advances
Istanbul Technical University
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Yuce et al. (Thu,) conducted a other in Bacterial infection (in vitro). Mitoxantrone vs. Clindamycin was evaluated on IC50 for translation inhibition. Mitoxantrone was identified as a translation inhibitor targeting the bacterial ribosome with an IC50 of 14.10 mM, demonstrating a bacteriostatic effect comparable to Clindamycin.
www.synapsesocial.com/papers/69d894ce6c1944d70ce05aee — DOI: https://doi.org/10.1039/d6ra01785a