Inositol supplementation is associated with improvements in biochemical hyperandrogenism in women with PCOS, with evidence of phenotype-dependent variability. The most consistent biochemical response was observed in normal-weight individuals. These findings support a metabolically informed, hypothesis-generating framework and highlight the need for adequately powered, phenotype-stratified trials incorporating clinically meaningful outcomes, including standardized measures of hirsutism, ovulatory function, and patient-reported endpoints.
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Daniele Tienforti
Gennaro Puocci
Claudia Venditti
Clinical Endocrinology
University of L'Aquila
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Tienforti et al. (Tue,) studied this question.
www.synapsesocial.com/papers/69d895d86c1944d70ce06f74 — DOI: https://doi.org/10.1111/cen.70140